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Journal of the National Cancer Institute Advance Access originally published online on August 11, 2008
JNCI Journal of the National Cancer Institute 2008 100(16):1126-1129; doi:10.1093/jnci/djn302
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© Oxford University Press 2008.

NEWS

Cancer Disparities: Disentangling the Effects of Race and Genetics

Vicki Brower

The first 150 words of the full text of this article appear below.

For certain cancers, African American patients have higher incidence and mortality rates than white Americans, but the reasons for this are not fully understood. Many recent studies have looked to genetics for an explanation, but, taken in isolation, these studies can raise more questions, and controversy, than they answer.

Recently, two sets of researchers both found that two genes, known as PSPHL and CRYBB2, that were not previously associated with cancer, are expressed at extremely high levels in African American breast and prostate cancer patients but not white patients. "We could tell with high accuracy by looking at the expression of those two genes which race the patients were. These differences may help explain the poorer prognoses seen among black and white patients with those diseases and may eventually help find better, more effective treatments for black patients with cancer, according to their tumor types," said Tiffany Wallace, Ph.D., research . . . [Full Text of this Article]

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