JNCI: Journal of the National Cancer Institute

Highlights

• LISTEN to JNCI Podcast: Issue 13 Summary
• Imatinib Resistance in Leukemia Patients Linked to LYN Kinase Activation
  Activation of LYN kinase is associated with resistance to imatinib in patients with chronic myelogenous leukemia.
  FREE: Persistent LYN Signaling in Imatinib-Resistant, BCR-ABL–Independent
  Chronic Myelogenous Leukemia
  
• NSAID Use Not Associated With Melanoma Risk
  Nonsteroidal anti-inflammatory drugs (NSAIDs) do not appear to be good candidates for melanoma chemoprevention, as no association was found between NSAID use and melanoma risk.
• Neuroblastoma Tumor Suppressor Gene Identified
  CHD5 is a tumor suppressor gene and is associated with survival outcome in neuroblastoma patients.

News

• Less Radiation After Lumpectomy in Breast Cancer: New Results Stir Debate
• Disease Progression in Some Cancers May Be Due to Low Blood Levels of Targeted Therapies
• Mapping Pathways From Stress to Cancer Progression
• Revised Guidelines Signal That Gene Expression Profiles Are Coming of Age